General Information

  • ID:  hor004900
  • Uniprot ID:  P05487
  • Protein name:  Conopressin-S
  • Gene name:  NA
  • Organism:  Conus striatus (Striated cone)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  Expressed by the venom duct.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pionoconus (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005185 neurohypophyseal hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0035821 modulation of process of another organism
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CIIRNCPRG
  • Length:  9
  • Propeptide:  CIIRNCPRG
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Interacts with high affinity with vasopressin V1b receptor (AVPR1B) (Ki=8.3 nM), although the displacement of specific [3H]vasopressin binding is incomplete (a 30-40% resistant component remained). Has weaker affinity binding for oxytocin receptor (OXTR) (Ki=175 nM), and V1a receptor (AVPR1A) (Ki=827 nM).Does not interact with V2R (up to 10 ¦ÌM)
  • Mechanism:  Negative results: does not interact with V2R (up to 10 uM).
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  1-6
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004900_AF2.pdbhor004900_ESM.pdb

Physical Information

Mass: 117414 Formula: C41H74N16O11S2
Absent amino acids: ADEFHKLMQSTVWY Common amino acids: CIR
pI: 8.83 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -5.56 Boman Index: -2314
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 86.67
Instability Index: 2298.89 Extinction Coefficient cystines: 125
Absorbance 280nm: 15.63

Literature

  • PubMed ID:  3680228
  • Title:  Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus striatus venoms.
  • PubMed ID:  18174156
  • Title:   Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.